Volume-6, Issue-8, August 2020

Abstract

Sepsis is a life-threatening organ dysfunction caused by dysregulation of the host's response to infection. Sepsis can lead to ketoacidosis in diabetes mellitus patients. A 60 years old male complained of headache, mild fever and painful swallowing since 2 weeks prior to hospital admission. History of diabetes mellitus is unknown. Based on examination, the working diagnosis for the patient was sepsis, suspected periapical abscess, type II diabetes mellitus with diabetic ketoacidosis and decreased consciousness. Initial management of sepsis, insulin, and endotracheal intubation were performed. The patient then was admitted to the ICU. Management of sepsis is very important and should be performed based on 1-hour SSC bundle while performing management of DKA. The patient had periapical abscess which is thought to be the source of sepsis. Sepsis then triggers DKA, and several organ dysfunctions in the form of AKI, DIC, and respiratory distress.

Keywords: Diabetic ketoacidosis, Periapical abscess, Sepsis.

References

Keywords: Diabetic ketoacidosis, Periapical abscess, Sepsis.

Abstract

Femoral shaft fractures are very demanding injuries to the patients and their families. Majority of cases occurs in children and adolescents. Titanium elastic nailing is one of the operative procedures for treatment of such fractures. So this present study was conducted on 30 diaphyseal femoral fracture patients aged 05-15 years treated with Titanium elastic nailing with the aim to assess the functional outcome of such cases in western Rajasthan scenario. It was found that. average time of union was found 6.33 weeks, average period of full weight bearing was 7.66 weeks and with average time 6.4 weeks. So it conclude that fracture of femur treated with Titanium Elastic Nailing has very good results that Titanium Elastic Nailing is an ideal device to treat pediatric femoral shaft fractures between age group 5-15 years.

Keywords: Femoral shaft fractures, diaphyseal femoral fracture, Titanium elastic nailing, Functional outcomes.

References

Keywords: Femoral shaft fractures, diaphyseal femoral fracture, Titanium elastic nailing, Functional outcomes.

Abstract

β-blockers like labetalol hydrochloride (LHCl) are potent and highly effective antihypertensive agents. The main drawback associated with β-blockers is extensive first-pass metabolism, variable bioavailability requiring frequent dose administration. This makes them an ideal candidate for transdermal therapeutic systems. β-blockers formulated as transdermal therapeutic system should enhance the bioavailability as well as improve patient compliance. Constant innovations and improvement in this field have potential that large-scale commercialization of transdermal dosage forms can be done. 

Aim: The aim of the present work was to develop and evaluate matrix type transdermal patches containing new polymeric combination to enhance the bioavailability as well as improve patient compliance. 

Materials and Methods: In present work development and evaluation of matrix-type transdermal patches containing a new polymeric combination of HPMC, carbopol934, ethyl cellulose, propylene glycol, polyethylene glycol, and isopropyl myristate for labetalol (LHCl) HCl (LBHCl). Film casting technique has been used in preparing patches. The patches were characterized for physical, in vitro release studies and ex vivo permeation studies using human cadaver skin. 

Result: F6 was found to be better than the other formulations and hence selected as the optimized formulation on the basis of results of evaluating parameters such as thickness, flatness, folding endurance, tensile strength, moisture content, moisture uptake, and drug content, formulation. The optimized patch was assessed for its pharmacokinetic, pharmacodynamic, skin irritation test and stability studies. 

Conclusion: Successful development of sustained release matrix type of transdermal patches which can show greater patient compliance in treating hypertension has been done.

Keywords: Drug delivery, labetalol hydrochloride, penetration enhancer, skin permeation, transdermal.

References

Keywords: Drug delivery, labetalol hydrochloride, penetration enhancer, skin permeation, transdermal.